ERK 1/2 Polyclonal Antibody, 50ul[BT-AP03057] Molecular Weight Markers A missense mutation in RBSN

A missense mutation in RBSN is associated with a defect in the early endocytic pathway

Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome| somatic and familial gastrointestinal stromal tumors| and a variety of other cancers

The protein localizes to the nucleus and the cytoplasm

It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates

ERK 1/2 Polyclonal Antibody, 50ul[BT-AP03057] Molecular Weight Markers A missense mutation in RBSNMAPK1 (mitogen activated protein kinase 1) encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon