PRT4165 - E3 Ubiquitin-ligase Bmi1/Ring1A Inhibitor. CAS# 31083-55-3 30002 Sanchez CG
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PRT4165 - E3 Ubiquitin-ligase Bmi1/Ring1A Inhibitor. CAS# 31083-55-3 30002 Sanchez CGPRT4165, CAS No. 31083 55 3, is a small molecule inhibitor of polycomb repressive complex 1, which inhibits ubiquitin signaling at DNA double strand breaks. PRT4165 is a potent inhibitor of PRC1 mediated H2A ubiquitylation in vivo and in vitro. The drug also inhibits the accumulation of all detectable ubiquitin at sites of DNA double strand breaks (DSBs), the retention of several DNA damage response proteins in foci that form around DSBs, and the
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