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This confirmed the role of oxidative stress in the pathogenesis of melasma

Oxidative stress gives rise to testicular tissue damages via DNA damage and increased lipid peroxidation in the long-chain polyunsaturated fatty acids of the testicle tissue [48]

Birth of the incretin concept The same year Lim and Kosaka published their hypothesis, the Belgian physiologist La Barre attempted to purify secretin with Eugene Still, a colleague at the University of Chicago