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Reports from recent studies reveal that gut microbial dysbiosis is an essential contributor to CKD pathophysiology and neurodegenerative conditions, making it a potent target for both early diagnosis of the disease and use in personalized treatment (Amini Khiabani et al., 2023

FIGURE 6 3.8 Alterations of cytochromes P450 (CYP) isoforms The presence of PAHs in HnB mainstream can change the expression of the main CYPs involved in the metabolism of these species (Pavek and Dvorak, 2008)