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HLY78 - Wnt Activator. CAS# 854847-61-3 60221 Following intravenous administration to mice

HLY78 - Wnt Activator. CAS# 854847-61-3 60221 Following intravenous administration to mice

Name: HLY78 - Wnt Activator. CAS# 854847-61-3 60221 Following intravenous administration to mice
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SKU: 76162715748
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SKU: 76162715748

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HLY78 - Wnt Activator. CAS# 854847-61-3 60221 Following intravenous administration to miceHLY78, CAS No. 854847 61 3, is an activator of the Wnt pathway by acting in a Wnt liganddependent manner, identified by a high throughput, cell based screen. HLY78 targets the DIX domain of Axin and potentiates the AxinLRP6 association, thus promoting LRP6 phosphorylation and Wnt signaling transduction. HLY78 may weaken the autoinhibition of Axin. In addition, HLY78 acts synergistically with Wnt in the embryonic development of zebrafish and increases

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Description

Following intravenous administration to mice at 5 mg/kg

pharmacodynamic

54(41):12020-4

Teperino R

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