AV-412 free base Catalog No.:M10578-10 A 65281 is a potent

A 65281 is a potent inhibitor of the P4-unknotting reaction

The inhibition of Top1 in HCC4017 cells is helpful to the toxicity of SW044248

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AV-412 free base Catalog No.:M10578-10 A 65281 is a potentAV 412, also known as MP 412, is a second generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR HER2 inhibitor AV 412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR HER2 expressing tumors. This agent may be active against EGFR HER2