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A lower lean-mass value does not automatically mean: The medication directly damaged the muscle The patient developed sarcopenia Strength declined Physical function deteriorated The patient is becoming frail The treatment caused disproportionate muscle wasting Recent methodological guidance emphasizes that body-composition terminology must be used carefully because lean tissue, fat-free mass, appendicular lean mass, and skeletal muscle refer to related but different biological compartments

Supplementary material The Supplementary Material for this article can be found online at: References 1 AbdelmasihR.SaeedZ.AshrafB.AbdelmaseihR.NasserH

Polypharmacy is a term that might sound complex, but it simply means the use of five or more medications at the same time (1-3)

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