Corynoxine B upitant metabolite Monohydroxy Netupitant PubMed PMID: 25130662
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Corynoxine B upitant metabolite Monohydroxy Netupitant PubMed PMID: 25130662Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin 1 dependent autophagy inducer. IC50 value: Target: Autophagy inducerin vitro: Corynoxine B, a natural autophagy inducer, restores the deficient cytosolic translocation of HMGB1 and autophagy in cells overexpressing SNCA, which may be attributed to its ability to block SNCA HMGB1 interaction . in vivo: Corynoxine B exhibited prolongation
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