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doi: 10.1007/978-1-0716-3429-5_1

Additionally, cofactors needed to optimize remethylation of homocysteine to form methionine are required to recycle the homocysteine to methionine for reuse as SAMe (Figure 54-10)

The reverse reaction in mammalian cells is catalyzed by acyl-protein thioesterases (APTs) in the cytosol and palmitoyl protein thioesterases in lysosomes