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It describes patients with overweight or obesity who want to improve metabolic markers and lower cardiovascular risk, and says ideal candidates typically have weight-related metabolic conditions, prediabetes, or type 2 diabetes alongside risk factors such as hypertension or dyslipidemia

Measurements of cAMP responses and ligand binding affinities in mutated GIP, GLP-1 and GCG receptors yielded similar results (Supplementary Fig