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Ultimately, inflammasome activation and IL-1 production lead to extracellular matrix deposition and kidney fibrosis 91,92

Additionally, TRIM72 has been found to decrease fibroblast proliferation to promote fibrosis, while the knockdown of TRIM8 has been clarified to reduce myocardial ischemia-reperfusion injury (Zhao and Lei, 2016

Researchers should note that tirzepatide is an FDA-approved medication for specific indications

Neuro-Endocrinol Lett 34:18599, PMID: 23685416 Shungu DC, Weiduschat N, Murrough JW, Mao X, Pillemer S, Dyke JP, Medow MS, Natelson BH, Stewart JM, Mathew SJ (2012) Increased ventricular lactate in chronic fatigue syndrome