S1RA Size:Solid 2 mg resulting in drug-induced apoptosis in

resulting in drug-induced apoptosis in K562 cells and a combination of apoptosis and cell cycle arrest in Bcr-Abl expressing BaF3 cells

Smiles: OC(=O)C=C(CCC1C=CC(Cl)=CC=1)C1C=CC=CC=1

demonstrates comparable pharmacodynamics and pharmacokinetics in older men and postmenopausal women

ML-329 shows specific activity against the MITF-dependent cells

S1RA Size:Solid 2 mg resulting in drug-induced apoptosis inE 52862, also known as S1RA and MR390, is a selective sigma 1 receptor antagonist, with a reported binding affinity of Ki = 17. 0 7. 0 nM, selective over the sigma 2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels. In preclinical studies, S1RA has demonstrated efficacy in relieving neuropathic pain and pain in other sensitizing conditions, associated with an improvement of the emotional negative state. E