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Moreover, AS-IV has been shown to mitigate obesity-related hypertension by repressing inflammatory responses and enhancing leptin resistance, likely through upregulation of 7nAchR levels and inhibition of IKK/NF-B signaling in the hypothalamus and adipose tissue (Jiang et al., 2018)

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Finally, if brain fog coincides with dose escalation, discussing a slower titration schedule with your PlexusDx clinician may reduce the intensity of adjustment symptoms while maintaining safety and efficacy