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Ferroptosis-based therapies offer significant advantages, including personalized treatment tailored to genetic profiles, potential to overcome drug resistance, and synergy with other therapeutic modalities [161]

395 Emerging medical therapies Several approaches are emerging to improve antistiffness drug therapy by targeting underlying pathophysiological mechanisms (Table 2)

For example, remicade, a clinically used anti-TNF- antibody targeting the p50 and p65 NF-B subtype of small interfering RNA and curcumin, a well-characterized natural NF-B inhibitor that is also a dominant negative inhibitor of B (IB), can inhibit GGT activation through distinct mechanisms

Amylin plays a critical role in satiety, gastric emptying, and blood glucose regulation