Endoplasmin Polyclonal Antibody, 50ul Subcellular Fractions Alternative splicing results in three

Alternative splicing results in three transcript variants which differ only in the 5' UTR

Multiple transcript variants encoding different isoforms have been found for BCLAF1

The precursor seems to be activated while it is being transported along the axon to the posterior pituitary

The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1

Endoplasmin Polyclonal Antibody, 50ul Subcellular Fractions Alternative splicing results in threeHSP90B1 encodes a member of a family of adenosine triphosphate (ATP) metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein (heat shock protein 90 beta family member 1) is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene.