SH2B3 Polyclonal Antibody, 100ul Lentiviral Packaging Knockout studies in mice suggest

Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system

is not inhibited by warfarin

Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080)| LYL1 (MIM 151440)| E2A (MIM 147141)| and SCL (MIM 187040)

Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease

SH2B3 Polyclonal Antibody, 100ul Lentiviral Packaging Knockout studies in mice suggestThis gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin dependent diabetes mellitus. Alternatively spliced