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Additionally, one group suggested that tumor-derived, rather than host PCSK9, is more important in facilitating melanoma growth based on in vivo findings, and further suggested this as a reason why anti-PCSK9 vaccination prior to tumor implantation, as in (Momtazi-Borojeni et al., 2020), may not be as effective in its anticancer effects (Gu et al., 2023)

Whitfield, 2001

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Furthermore, numerous studies indicate that reactive oxygen species (ROS) may need to interact with other intracellular signals, such as inflammatory factors or changes in ion channels, to effectively induce the assembly and activation of the NLRP3 inflammasome [288]