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Serine 202 phosphorylation also results in migration of PKM2 to the nucleus and this modification allows PKM2 to serve as a transcriptional co-activator of the transcription factors STAT3 (signal transducer and activator of transcription 3) and STAT5A (signal transducer and activator of transcription 5A)

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Altogether, compared to free YHV984, the formulated T7-LNP@YHV984 demonstrated more pronounced efficacy in inhibiting Hv1 expression, promoting microglial M2 polarization, secreting more anti-inflammatory cytokines to quell neuroinflammation, and safeguarding neuronal survival in the injured brain tissue of mice post-IS

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