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The apparent increased risk of NAION must be considered in context, as GLP-1 receptor drugs have provided considerable benefit to millions of users, including an increased chance of improved management of type 2 diabetes, substantial reduction in body weight, substantially improved morbidity and mortality of major adverse cardiovascular events and even reduced addictive behaviors, they noted

An initial dose escalation period is necessary for XENPOZYME 1 Pediatric dose escalation and maintenance* The maintenance dose of 3 mg/kg is reached gradually, according to the biweekly dose escalation regimen in a clinical setting, over at least 16 weeks for pediatric patients