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The twice-daily dosing requirement and gastrointestinal side effects have limited its use compared to newer, longer-acting alternatives

Pharmacol., 128, 1385-1392 9

The prevalence of OH in Long Term Residential settings vs Community-Dwelling older People incorporating the quality of the studies (six studies with a sample of 2,694) into the pooled analysis revealed a prevalence of 22.2% vs 18.4% respectively