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Even if you meet the diagnostic criteria weve discussed, you would not be indicated for a weight loss peptide if you are: Pregnant Animal studies show that the offspring of pregnant subjects exposed to GLP-1 RAs may develop skeletal abnormalities, have a low birth weight, and exhibit substandard growth.23 Although no congenital malformations have been widely identified in humans, people who are pregnant or planning to become pregnant are advised to forgo or end their GLP-1 RA treatment