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For current practice, the most defensible use of GLP-1RAs is as a time-bounded metabolic optimization strategy in women with meaningful obesity/insulin-resistance burden, with reproductive endpoints interpreted as potential downstream gains rather than guaranteed direct effects (111, 112, 124)

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Mechanisms of Anti-Inflammatory Action The anti-inflammatory action of GLP-1 medications stems from their ability to inhibit pro-inflammatory cytokines like TNF-, IL-6, and CRP