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Potential selection criteria might include: Adolescents with BMI 95th percentile for age and sex History of unsuccessful comprehensive lifestyle interventions Presence of obesity-related comorbidities Absence of contraindications (eating disorders, severe mental illness) Adequate family support and resources for monitoring Informed consent and assent processes completed Monitoring and Follow-up Comprehensive monitoring protocols are essential for safe and effective use of GLP-1 RAs in adolescents

We summarize advances in research on urate -lowering drugs including urate transporter inhibitors, xanthine oxidase inhibitors as well as novel urate -lowering drugs, and evaluate the effect of urate-lowering therapy on the rate of hyperuricaemia-related diseases