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There are also several medical conditions and environmental factors that will deplete your bodys glutathione supply quicker than it can make it, including: UV radiation exposure Exposure to chemical toxins, including pollution Cadmium exposure (found in zinc by-products and spent nickel-cadmium batteries) Excessive alcohol use Chronic stress Certain medications Sickness and infections Smoking Poor diet Genetic deficiencies When your body is suffering from glutathione deficiency, you may experience several symptoms, including: Headaches/dizziness Difficulty concentrating Chronic fatigue and/or weakness Moodiness and/or depression Painful joints Difficulty sleeping Dermatitis Frequent colds How IV Glutathione Therapy Works Studies have shown that eating or drinking glutathione supplements isnt an effective way to increase your bodys glutathione levels