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Nooms physician-designed program employs a low and slow titration approach with microdoses that are a fraction of conventional maintenance doses

doi: 10.1136/gutjnl-2013-306393 5 BorthakurA.SaksenaS.GillR

The insulin-mediated signaling pathway that triggers production of NO in vascular endothelium involves the same signaling proteins (PI3K, PDPK1, and AKT/PKB) that are components of metabolic regulatory pathways induced by insulin