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Retatrutide is not yet approved in the UK and remains in clinical trials UK regulatory approval could potentially come in late 2025 or 2026 Current alternatives like Mounjaro and Wegovy are available now through private prescription Most patients will need to access these medications privately due to NHS restrictions Costs for current medications range from approximately 150-300 per month Managing Expectations and Preparing for Treatment If you are considering retatrutide or similar medications for PCOS management, setting realistic expectations is crucial for treatment success

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Approximately 20%-30% of individuals with MASLD progress to MASH, characterized by hepatocyte ballooning, lobular inflammation, and variable fibrosis, and 10%-20% of MASH patients develop advanced fibrosis (stages F3-F4) or cirrhosis over their lifetime [6,13]