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Quercetin pretreatment significantly inhibits LPS-induced apoptosis and inflammation to alleviate RTEC injury, including brush border loss, vacuolization, inflammatory cell infiltration, and necrosis by upregulating SIRT1 expression, inhibiting the NF-B activity and reducing the expression of related pro-inflammatory factors (the level of IL-6, IL-1 and TNF-) and pro-apoptotic protein (cleaved caspase-3, Bax and cleaved caspase-9) (Lu et al., 2021)

Weekly subcutaneous injection Tirzepatide activates both GLP-1 and GIP receptors, producing larger average weight loss than semaglutide in head-to-head trials

Several non-hormonal medications effectively reduce night sweats for women who cannot or prefer not to use HRT