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Tirzepatide works by allowing GIP and GLP-1 to stimulate the pancreas to increase the amount of insulin released in response to meals, encouraging healthy blood glucose regulation

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Bruker) on the Evosep ONE HPLC system using the 30 samples per day method, then injected through a CaptiveSpray ion source and 20 m emitter into a timsTOF Pro 2 mass spectrometer (Bruker) operated in diaPASEF mode