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and (3) metabolites synthesized de novo by the microbiota, such as lipopolysaccharide (LPS) (34)

Funding This work was supported by the National Natural Science Foundation of China (82370768)

Chronic sleep deprivation or poor sleep quality impairs these restorative processes, potentially reducing glutathione synthesis capacity and increasing oxidative stress through various mechanisms including increased inflammatory signaling, impaired glucose metabolism, disrupted circadian rhythms affecting antioxidant enzyme expression, and increased psychological stress responses