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Figure 5 illustrates how the solid tumor microenvironment (TME) drives treatment resistance

In women with PMOS, that environment carries higher oxidative load than in non-PCOS controls, which is one of the mechanisms proposed for the egg-quality challenges sometimes seen in PCOS fertility workups

Surgery carries surgical risks and requires permanent dietary modifications

It may also be worthwhile to reanalyze gene expression datasets obtained from CaP models in which coregulator function is altered and apply ceRNA analyses to gain insights into cooperating transcript networks