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If GLP-1 medications reduce oral progesterone absorption, the endometrial protection could be compromised

Slower titration for sensitive patients If you experienced significant GI side effects on semaglutide, your provider may recommend a slower approach: Staying at 2.5 mg for 6 to 8 weeks instead of 4 Moving to 3.75 mg (compounded only) before 5 mg Extending each dose level by 2 weeks based on side effect severity This conservative approach takes longer to reach therapeutic doses but results in better long-term adherence

Does weight loss from semaglutide help or hurt GERD

If the absorption changes significantly, it could lead to a higher level of the blood thinner in your system, which is why your doctor will monitor you closely for any signs of unusual bruising or bleeding