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any temperature excursion above 8C causes irreversible peptide denaturation

His team is best known for identifying MOTS -c, which has been called an exercise mimetic: it activates cellular pathways that are usually turned on during exercise

The peptide activates vascular endothelial growth factor receptor 2 (VEGFR2), triggering the VEGFR2-Akt-eNOS pathway, which promotes angiogenesis and improves blood flow to damaged tissue