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Because the shot is fast and performed by trained staff, many patients find that the convenience outweighs any temporary discomfort

2 The British Society for Haematology recommends intramuscular vitamin B 12 for severe deficiency and malabsorption syndromes, whereas oral replacement may be considered for patients with asymptomatic, mild disease with no absorption or compliance concerns

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J Pharmacol Exp Ther 171(1):8087 Johnson DG, Thoa NB, Weinshilboum R, Axelrod J, Kopin IJ (1971) Enhanced release of dopamine--hydroxylase from sympathetic nerves by calcium and phenoxybenzamine and its reversal by prostaglandins