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Yang L, et al

Hormonal and Environmental Factors Breakouts occurring after glutathione treatment may be coincidental and related to: Stress Hormonal changes Diet Sleep disruption Existing acne-prone skin For this reason, it can be difficult to attribute acne solely to glutathione treatment

While numerous animal studies ( in vivo ) show significant effects on hormone levels and immune parameters, clinical trial data in humans remains limited for most interventions

However, silencing HO-1 increases the growth inhibition of hepatocellular carcinoma (HCC) cells after ferroptosis triggering, suggesting that HO-1 also has an anti-ferroptosis effect (36)