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Week 1 Day 1 : 25mg Day 2 : 50mg Day 3 : 75mg Days 47 : 100mg per day Week 2 100mg per day for 7 days Week 3 and Onward 100mg every other day or 34 times per week Each injection may last in effect for 4 to 6 weeks depending on NAD+ levels

Fullerene derivatives activate apoptosis-regulating kinase 1 (ASK1) and c-Jun N-terminal kinase (JNK) signaling pathways, activating oxidative stress and influencing the proliferation of hepatocellular carcinoma cells, further leading to cellular JAK2 V617F mutation

doi:10.1007/s11325-014-0940-x Li J, Yu LQ, Jiang M, Wang L, Fang Q

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