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It is the most clinically studied of the three, with topical trials showing collagen, fine-line, and skin-density changes, and a large body of in-vitro work on gene expression and wound healing

Across the various development stages, from Phase I to pre-registration, 101 different companies have contributed at least one novel drug candidate to the development pipeline, (Figure 3 a), indicative of the perceived opportunity that continues to exist in the medical management of obesity

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