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In a 26-week double-blind trial (Trial 1, NCT02906930), 703 adult patients with type 2 diabetes mellitus inadequately controlled with diet and exercise were randomized to semaglutide tablets 3 mg, semaglutide tablets 7 mg or semaglutide tablets14 mg orally once daily or placebo

Consistent weekly dosing is essential for maintaining suppressed hunger and steady weight loss

Antithrombotic Effects GLP-1 agonists reduce cardiovascular events through several mechanisms previously summarized to include improved glycemic control, weight loss, lowering blood pressure, lipid lowering, reduced atherogenesis, attenuated vascular inflammation, improved endothelial cell function, vasodilation, and direct cardiovascular protective effects [88, 89]

Following this logic, clearance of lipid-rich debris derived from dying adipocytes by LAMs could prevent toxic effects on neighbouring cells