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This disparity led to the accumulation of hydrogen peroxide (H 2 O 2 ), as evidenced by heightened lipid peroxidation and diminished mitochondrial complex-I activity, ultimately inducing apoptosis

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While the condition is the major cause of poor vitamin B 12 status in the elderly population, it is usually associated with atrophic gastritis, a chronic inflammation of the lining of the stomach that ultimately results in the loss of glands in the stomach (atrophy) and decreased stomach acid production (see Atrophic gastritis)