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SGLTs are expressed on the apical membrane, bringing sodium ions down their concentration gradient into the epithelial cell and allowing the glucose molecule to enter the cell against its concentration gradient

"This is exactly why we have to do double-blind placebo-controlled studies, to look not only at the efficacy, as we hope, but also safety, in particular, because people with alcohol use disorder and addiction in general often have a comorbidity with other mental health problems, including depression," Leggio said, stressing the importance of monitoring closely for depressive symptoms